Annie
[to George] Seriously? You're equating your pathetic love life with my record-breaking tumor? Seriously?
Miranda Bailey
Fools on bikes killing themselves. Natural selection is what it is.
Meredith Grey
You don't know this yet, but life isn’t supposed to be like this. It’s not supposed to be this hard.
Meredith Grey
The thing people forget is how good it can feel when you finally set secrets free. Whether good or bad, at least they're out in the open. And once your secrets are out in the open, you don't have to hide behind them anymore. The problem with secrets is even when you think you're in control, you're not.
Mackie
No, liver cancer will kill me, smoking will just speed up the process.
George O'Malley
I'm putting my foot down, either the dog moves out or I do. Foot down now. Me or the dog, which is it?
George O'Malley
I'm going to have to dodge Burke for the rest of my career. He could kill me and make it look like an accident.
Derek Shepherd
You know, you might want to leave. Before I change my mind and let her beat you to a pulp with her tiny, ineffectual fists.
Derek Shepherd
[to Meredith who is drinking tequila and dancing in her front lawn] So you blew me off for a bottle of tequila? Tequila's no good for you. It doesn't call, doesn't write, not nearly as much fun to wake up to.
Cristina Yang
I need a drink, a man, or a massage. Or a drunken massage by a man.
Cristina Yang
I blame the babies, they make you toxic.

